Christopher Francklyn : rechercher sur Z-Library

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Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia

Mindy Farris, Astrid Lague, Zara Manuelyan, Jacob Statnekov, Christopher Francklyn

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2012

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2012

Proteobacterial Histidine-Biosynthetic Pathways Are Paraphyletic

Jeffrey P. Bond, Christopher Francklyn

Journal:

Journal of Molecular Evolution

Année:

2000

Langue:

english

Fichier:

PDF, 955 KB

english, 2000

Aminoacylation of RNA minihelices with alanine

Francklyn, Christopher, Schimmel, Paul

Journal:

Nature

Année:

1989

Fichier:

PDF, 442 KB

1989

10.1038/84901

Francklyn, Christopher S.

Journal:

Natural Structural Biology

Année:

2001

Langue:

english

Fichier:

PDF, 921 KB

english, 2001

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

Qiu, Hongfang, Dong, Jinsheng, Hu, Cuihua, Francklyn, Christopher S., Hinnebusch, Alan G.

Journal:

The EMBO Journal

Année:

2001

Langue:

english

Fichier:

PDF, 591 KB

english, 2001

Substrate Specificity and Catalysis by the Editing Active Site of Alanyl-tRNA Synthetase from Escherichia coli

Pasman, Zvi, Robey-Bond, Susan, Mirando, Adam C., Smith, Gregory J., Lague, Astrid, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.96 MB

english, 2011

Aminoacylation at the Atomic Level in Class IIa Aminoacyl-tRNA Synthetases

Arnez, John G., Sankaranarayanan, Rajan, Dock-Bregeon, Anne-Catherine, Francklyn, Christopher S., Moras, Dino

Journal:

Journal of Biomolecular Structure and Dynamics

Année:

2000

Langue:

english

Fichier:

PDF, 154 KB

english, 2000

DNA Polymerases and Aminoacyl-tRNA Synthetases: Shared Mechanisms for Ensuring the Fidelity of Gene Expression†

Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2008

tRNA as an active chemical scaffold for diverse chemical transformations

Christopher S. Francklyn, Anand Minajigi

Journal:

FEBS Letters

Année:

2010

Langue:

english

Fichier:

PDF, 534 KB

english, 2010

Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs

Christopher FRANCKLYN, Karin MUSIER-FORSYTH, Paul SCHIMMEL

Journal:

FEBS Journal

Année:

1992

Langue:

english

Fichier:

PDF, 866 KB

english, 1992

Crystallization of Histidyl-tRNA Synthetase from Escherichia coli

Christopher Francklyn, Deborah Harris, Dino Moras

Journal:

Journal of Molecular Biology

Année:

1994

Fichier:

PDF, 178 KB

1994

Catalytic defects in mutants of class II histidyl-tRNA synthetase from Salmonella typhimurium previously linked to decreased control of histidine biosynthesis regulation

Christopher Francklyn, Jodi Adams, John Augustine

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 987 KB

english, 1998

Distinct Kinetic Mechanisms of the Two Classes of Aminoacyl-tRNA Synthetases

Chun-Mei Zhang, John J. Perona, Kang Ryu, Christopher Francklyn, Ya-Ming Hou

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 578 KB

english, 2006

Kinetic Discrimination of tRNA Identity by the Conserved Motif 2 Loop of a Class II Aminoacyl-tRNA Synthetase

Ethan C. Guth, Christopher S. Francklyn

Journal:

Molecular Cell

Année:

2007

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2007

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

Christopher S. Francklyn, Eric A. First, John J. Perona, Ya-Ming Hou

Journal:

Methods

Année:

2008

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2008

Transfer RNA–Mediated Editing in Threonyl-tRNA Synthetase: The Class II Solution to the Double Discrimination Problem

Anne-Catherine Dock-Bregeon, Rajan Sankaranarayanan, Pascale Romby, Joel Caillet, Mathias Springer, Bernard Rees, Christopher S Francklyn, Chantal Ehresmann, Dino Moras

Journal:

Cell

Année:

2000

Langue:

english

Fichier:

PDF, 473 KB

english, 2000

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Williams, Tamara F., Mirando, Adam C., Wilkinson, Barrie, Francklyn, Christopher S., Lounsbury, Karen M.

Journal:

Scientific Reports

Année:

2013

Langue:

english

Fichier:

PDF, 868 KB

english, 2013

The Quaternary Structure of the HisZ−HisG N -1-(5‘-Phosphoribosyl)-ATP Transferase from Lactococcus lactis †

Bovee, Michael L., Champagne, Karen S., Demeler, Borries, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 134 KB

english, 2002

The α-Amino Group of the Threonine Substrate as The General Base During tRNA Aminoacylation: A New Version of Substrate-Assisted Catalysis Predicted by Hybrid DFT

Huang, WenJuan, Bushnell, Eric A. C., Francklyn, Christopher S., Gauld, James W.

Journal:

Journal of Physical Chemistry A

Année:

2011

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2011

Fidelity Escape by the Unnatural Amino Acid β-Hydroxynorvaline: An Efficient Substrate for Escherichia coli Threonyl-tRNA Synthetase with Toxic Effects on Growth

Minajigi, Anand, Deng, Bin, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2011

Molecular dissection of a transfer RNA and the basis for its identity

Hou, Ya-Ming, Francklyn, Christopher, Schimmel, Paul

Journal:

Trends in Biochemical Sciences

Année:

1989

Langue:

english

Fichier:

PDF, 624 KB

english, 1989

Arabinose-Induced Binding of AraC Protein to araI2Activates the araBAD Operon Promoter

Nancy Lee, Christopher Francklyn and Eileen P. Hamilton

Journal:

Proceedings of the National Academy of Sciences

Année:

1987

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1987

The First Step of Aminoacylation at the Atomic Level in Histidyl-tRNA Synthetase

John G. Arnez, John G. Augustine, Dino Moras and Christopher S. Francklyn

Journal:

Proceedings of the National Academy of Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1997

An Aminoacyl-tRNA Synthetase Paralog with a Catalytic Role in Histidine Biosynthesis

Marie Sissler, Christine Delorme, Jeff Bond, S. Dusko Ehrlich, Pierre Renault and Christopher Francklyn

Journal:

Proceedings of the National Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 1.58 MB

english, 1999

10.1038/75856

Moras, Dino, Sankaranarayanan, Rajan, Dock-Bregeon, Anne-Catherine, Rees, Bernard, Bovee, Michael, Caillet, Joel, Romby, Pascale, Francklyn, Christopher S.

Journal:

Natural Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 380 KB

english, 2000

Covariation of a Specificity-Determining Structural Motif in an Aminoacyl-tRNA Synthetase and a tRNA Identity Element †

Hawko, Susan A., Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 172 KB

english, 2001

Substrate Recognition by the Hetero-Octameric ATP Phosphoribosyltransferase from Lactococcus lactis †

Champagne, Karen S., Piscitelli, Elise, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 733 KB

english, 2006

Standardizing Analysis of Circulating MicroRNA: Clinical and Biological Relevance

Farina, Nicholas H., Wood, Marie E., Perrapato, Scott D., Francklyn, Christopher S., Stein, Gary S., Stein, Janet L., Lian, Jane B.

Journal:

Journal of Cellular Biochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2014

G−1:C73 Recognition by an Arginine Cluster in the Active Site of Escherichia coli Histidyl-tRNA Synthetase †

Connolly, Susan A., Rosen, Abbey E., Musier-Forsyth, Karin, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 169 KB

english, 2004

Design of an Active Fragment of a Class II Aminoacyl-tRNA Synthetase and Its Significance for Synthetase Evolution †

Augustine, John, Francklyn, Christopher

Journal:

Biochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 366 KB

english, 1997

A nucleotide that enhances the charging of RNA minihelix sequence variants with alanine

Shi, Jian Ping, Francklyn, Christopher, Hill, Kelvin, Schimmel, Paul

Journal:

Biochemistry

Année:

1990

Langue:

english

Fichier:

PDF, 1.93 MB

english, 1990

Synthetic RNA molecules as substrates for enzymes that act on tRNAs and tRNA-like molecules

Francklyn, Christopher S., Schimmel, Paul

Journal:

Chemical Reviews

Année:

1990

Langue:

english

Fichier:

PDF, 4.90 MB

english, 1990

tRNA Discrimination at the Binding Step by a Class II Aminoacyl-tRNA Synthetase †

Bovee, Michael L., Yan, Wen, Sproat, Brian S., Francklyn, Christopher S.

Journal:

Biochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 199 KB

english, 1999

A Substrate-Assisted Concerted Mechanism for Aminoacylation by a Class II Aminoacyl-tRNA Synthetase †

Guth, Ethan, Connolly, Susan H., Bovee, Michael, Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 161 KB

english, 2005

A tRNA Identity Switch Mediated by the Binding Interaction between a tRNA Anticodon and the Accessory Domain of a Class II Aminoacyl-tRNA Synthetase †

Yan, Wen, Augustine, John, Francklyn, Christopher

Journal:

Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 425 KB

english, 1996

Induced Fit and Kinetic Mechanism of Adenylation Catalyzed by Escherichia coli Threonyl-tRNA Synthetase †

Bovee, Michael L., Pierce, Melissa A., Francklyn, Christopher S.

Journal:

Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 212 KB

english, 2003

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

Novoa, Eva Maria, Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Marín-García, Patricia, Azcárate, Isabel G., Bautista, José M., Mirando, Adam C., Francklyn, Christopher S., Varon, Sònia

Journal:

Proceedings of the National Academy of Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2014

Enzymatic Aminoacylation of an Eight-Base-Pair Microhelix with Histidine

Christopher Francklyn and Paul Schimmel

Journal:

Proceedings of the National Academy of Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 1.21 MB

english, 1990

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

Scaringe, Stephen A., Francklyn, Christopher, Usman, Nassim

Journal:

Nucleic Acids Research

Année:

1990

Langue:

english

Fichier:

PDF, 4.32 MB

english, 1990

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Fang, Pengfei, Yu, Xue, Jeong, Seung Jae, Mirando, Adam, Chen, Kaige, Chen, Xin, Kim, Sunghoon, Francklyn, Christopher S., Guo, Min

Journal:

Nature Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2015

Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation

FRANCKLYN, CHRISTOPHER, PERONA, JOHN J., PUETZ, JOERN, HOU, YA-MING

Journal:

RNA

Année:

2002

Langue:

english

Fichier:

PDF, 688 KB

english, 2002

Transfer RNA and human disease

Abbott, Jamie A., Francklyn, Christopher S., Robey-Bond, Susan M.

Journal:

Frontiers in Genetics

Année:

2014

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2014

Regulation of Angiogenesis by Aminoacyl-tRNA Synthetases

Mirando, Adam, Francklyn, Christopher, Lounsbury, Karen

Journal:

International Journal of Molecular Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2014

Aminoacyl-Transfer RNA Synthetases

Lounsbury, Karen M., Francklyn, Christopher S.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 763 KB

english, 2016

Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry

Abbott, Jamie A., Livingston, Nathan M., Egri, Shawn B., Guth, Ethan, Francklyn, Christopher S.

Journal:

Methods

Année:

2016

Langue:

english

Fichier:

PDF, 718 KB

english, 2016

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Mirando, Adam C., Fang, Pengfei, Williams, Tamara F., Baldor, Linda C., Howe, Alan K., Ebert, Alicia M., Wilkinson, Barrie, Lounsbury, Karen M., Guo, Min, Francklyn, Christopher S.

Journal:

Scientific Reports

Année:

2015

Langue:

english

Fichier:

PDF, 1.87 MB

english, 2015

Aminoacyl-tRNA synthetases

Francklyn, Christopher

Journal:

Methods

Année:

2017

Langue:

english

Fichier:

PDF, 242 KB

english, 2017

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity

Abbott, Jamie A., Guth, Ethan, Kim, Cindy, Regan, Cathy, Siu, Victoria M., Rupar, Charles Anthony, Demeler, Borries, Francklyn, Christopher S., Robey-Bond, Susan M.

Journal:

Biochemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2017

11th IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases: Sailing a New Sea of Complex Functions in Human Biology and Disease

Francklyn, Christopher, Roy, Herve, Alexander, Rebecca

Journal:

Biomolecules

Année:

2018

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2018

Immunity guided identification of threonyl-tRNA synthetase as the molecular target of obafluorin, a beta-lactone antibiotic

Scott, Thomas A, Batey, Sibyl F. D., Wiencek, Patrick, Chandra, Govind, Alt, Silke, Francklyn, Christopher S., Wilkinson, Barrie

Journal:

ACS Chemical Biology

Année:

2019

Langue:

english

Fichier:

PDF, 929 KB

english, 2019